Pfizer Senior Associate Scientist, ADME in Groton, Connecticut
This scientist will provide high quality in vitro plate-based ADME, safety and biopharmaceutical data to project teams to enable rapid decision making in support of the Worldwide Research and Development (WRD) portfolio. A key responsibility for this group includes serving as the lead for one of Hit Discovery and Optimization's (HDO) screening modules.
This scientist will play a key role in optimizing the workflows, logistics and flexible resources involved in producing data related to the HDO screening module.
• This scientist will serve as the HDO screening module point of accountability to WRD project teams.
• This scientist will play a key role in developing, optimizing and validating ADME, safety and biopharmaceutical assays and workflows using cutting edge in vitro models and technology solutions.
This scientist will partner with Medicines Design project team members, Discovery Sciences counterparts and CROs and contractors to deliver on the portfolio.
The successful candidate will join a team of scientists within the Hit Discovery and Optimization (HDO) group which is focused on the design, optimization, implementation and execution of in vitro plate-based screening modules supporting early research unit portfolios. This group drives the evaluation and utilization of novel plate-based screening sciences, technologies and workflows to improve or add capabilities within ADME, safety and biopharmaceutical property evaluation and optimization. Finally, the group interacts with project teams and counterparts as points of accountability to support and drive impactful use and design of HDO's screening modules.
As a member of a laboratory focused on providing data to profile and optimize lead matter quality through in vitro assay development, optimization, implementation and execution, the primary responsibilities of this role will include leading one of HDO's screening modules. More specifically, leading a screening module will include a focus on continuous improvement of all elements of the screening module (assays, logistics, technologies), driving the screening sciences related to the screening module, and effectively interfacing with client groups and counterparts to serve as the primary point of contact for the screening module. Additional responsibilities for this role include contributing to novel ADME, safety and / or biopharmaceutical assay platform development and departmental scientific initiatives. The HDO group utilizes flexible resources extensively, and this role may be required to interact with external data providers and / or contingent workers, including oversight to ensure high quality data is being produced. Applicants must have experience working in an experimental laboratory to enable success in understanding and executing a wide range of assay technologies for the various ADME, safety and biopharmaceutical assay platforms routinely employed by HDO. Previous experience in delivering data using these aforementioned platforms in a drug discovery setting is desired. Also critical to the role is familiarity and/or comfort with high-throughput screening techniques and equipment, and ability to learn new software applications quickly (e.g., Biobook, Excel, Analyst, Galileo, Spotfire). The successful candidate will be excited by a role with high demands, working in teams with multiple partners including client and counterpart groups. The candidate should therefore possess strong collaborative and written/verbal communication skills and an enthusiastic, optimistic attitude. He/she should demonstrate strong leadership skills, flexibility, and be adept at multi-tasking and building partnerships.
Successful candidates will be expected to:
Develop, optimize and validate assays as well as execute plate-based in vitro assays and data analysis.
Have an understanding and ability to optimize and troubleshoot logistics, IT systems and workflows utilized to execute HDO's screening modules.
Proactively respond to project team needs for special studies to answer specific questions related to the screening modules.
Have experience with multiple ADME, safety and / or biopharmaceutical in vitro assay formats.
Display consistent proficiency in automated data acquisition, analysis and quality control; provide timely, high quality data to project teams.
Adopt a key enabling responsibility including enterprise data quality and vendor oversight best practices, automation and oversight of reagent database.
Serve as a resource for technical, biological and drug discovery expertise.
Use robotics and automation in the performance of screening including optimization, troubleshooting and routine programming.
Be skilled in assay transfer and data management (e.g., optimizing assays from other groups in Medicines Design and DSRD and effectively establishing screens with external vendors).
Adopt a continuous improvement mindset to improve speed (turnaround time of screening data), quality, efficiency and/or cost of processes within lab.
Maintain up to date electronic laboratory notebooks and records in accordance with Pfizer policy.
Comply with all safety training and good laboratory practices. Additional role attributes:
Contributes to achievement of goals at the work group/ project team level as a full team participant and influences work at this level. Decisions frequently impact whole work group/project team.
Has deep knowledge of varied aspects or a specialized aspect of a discipline.
Recognized as a technical expert with growing scientific contributions and acts as a resource within own work group/project team. Provides formal/informal mentoring within work group/project team.
Applies technical skills and functional knowledge to projects/ assignments within own work group/ project team independently and proactively.
Uses own scientific judgment to apply and adapt standard methods and techniques by applying prior work experience, consulting others appropriately.
May use or develop novel processes or hypotheses; new ideas and knowledge are used frequently.
Makes decisions that require choosing between multiple options or may develop new options to resolve moderately complex problems.
May work in ambiguous situations within own work group/ project team.
Significant uncertainty of successful technical outcome for many of solutions attempted.
Receives instructions primarily on unusual or complex problems.
Manages own time to meet agreed targets; develops plans for short-term work activities on own projects (timelines, work plans, deliverables).
Works under limited supervision with periodic review of achievement of results and methods used. Basic Qualifications
Minimum qualification BS or MS in a relevant science (e.g., biology, chemistry, or Pharmacy) with 5+ years of relevant experience to drug discovery in ADME, safety, biology, cell biology, or chemistry.
At least 3 years prior experience in a laboratory working as part of a multi-disciplinary team focused on delivering in vitro ADME, safety and / or biopharmaceutical data.
Experience developing new assays using a variety of plate-based ADME, safety or biopharmaceutical assay formats (metabolic stability, transwell, enzymology, reporter assays, physical properties assays).
Demonstrated experience with standard in vitro ADME, safety, and/or biopharmaceutical assays (e.g. microsomal and hepatic stability, permeability and efflux assays, ATP reporter assays, physical properties assays), including assay transfer, execution and troubleshooting.
Strong track record of delivering high quality data meeting the needs of teams.
Successful experience partnering with stakeholder groups and maintaining a customer focus.
Experience of interacting with other groups in related areas such as materials management, automation and informatics is desired.
Excellent computer, verbal and written communication skills.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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Additional Offer Details:
Last Date to Apply for Job: July 31, 2017
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